AI Discovery

AstraZeneca

BenevolentAI

Cardiovascular,

Immunology

심부전

전신홍반성루푸스

AI discovery

AI-driven drug discovery

u/d

u/d

Sanofi*

Exscientia

Oncology, Immunology

종양, 면역질환

AI discovery

AI-driven drug discovery/development focused on precision medicine

$100m

u/d

Shanghai Fosun Pharma

Insilico Medicine

Oncology

면역항암 및

다양한 질환

AI discovery

AI-driven drug discovery/development ;

co-development of a program aimed at checkpoint protein

$13m

u/d

Amgen

Generate Biomedicine

u/d

u/d

AI discovery

AI-driven drug discovery/development for protein therapeutics across multiple modalities

$50m

$370m

MSD

Absci

u/d

u/d

AI discovery

AI-driven drug discovery/development focused on non-standard amino acid technology

u/d

$610m

    Antibodies

AstraZeneca*

Neurimmune

Cardiovascular

트랜스티레틴 아밀로이드 심근병증

mAb

Monoclonal antibody

$30m

$730m

Novartis*

Molecular Partners

Infectious Disease

코로나

DARPin

DARPin-based antiviral

$66m

$163m

Coherus Biosciences*

Shanghai Junshi Biosciences

Oncology

고형암

antibody

TIGIT-targeted antibody

$35m

$255m

Pfizer

DrenBio

Oncology

종양

bispecific

Bispecific antibodies (myeloid cell engagers)

$25m

$1b

Bristol Myers Squibb

Prellis

u/d

u/d

other

Human antibody libraries

u/d

u/d

    Cell Therapy

Bristol Myers Squibb

Evotec

CNS

신경퇴행성질환

iPS

Novel targeted protein degradation approach (iPSC)

u/d

$15m

Bristol Myers Squibb*

Century Therapeutics

Oncology

급성골수성백혈병,

다발골수종

iPS

iPS cell-derived allogeneic immune cell therapies

$150m

$3b

Bristol Myers Squibb

ArsenalBio's

Oncology

혈액암, 골수암, 고형암

T-cell

Programmable T cell therapy

$70m

u/d

    Gene Therapy

DiNAQOR

Children's Medical Research Institution

Cardiovascular

심혈관계 질환

AAV

Bioengineered adeno-associated virus (AAV) capsids

u/d

u/d

Pfizer

Beam Therapeutics

CNS,

Gastroenterology

희귀 유전 중추신경계 및

근육, 간질환

base editing

In vivo base editing (mRNA+LNP)

$300m

1.05b

Bayer

Mammoth Biosciences

Gastroenterology

간질환

CRISPR editing

"Ultra-small" CRISPR-based gene editing therapies

$40m

$1b

Novo nordisk

2Seventy Bio

Hepatology

혈우병 A

Talen editing

In vivo gene editing treatment

$5m

$35m

Moderna

Carisma Therapeutics

Oncology

종양

CAR-M

In vivo engineered chimaeric antigen receptor monocyte (CAR-M) therapeutics

$80m

u/d

Sana*

IASO Bio/Innovent

Oncology

난치성 다발골수종

CAR-T

BCMA-targeting CAR-T cells therapies (in vivo) and hypoimmune cell therapies (ex vivo)

u/d

$204m

Sana*

NIH

Oncology

B세포 림프종

CAR-T

In vivo/ex vivo CD22-targeting CAR-T cell therapies

u/d

u/d

Allogene

Antion

u/d

u/d

CAR-T

miRNA based allogeneic CAR-T therapies

u/d

u/d

Selecta

Ginkgo Bioworks

u/d

u/d

u/d

Next-generation gene therapy viral capside

u/d

$1.1b

    RNA

Acadia Pharmaceuticals

Stoke Therapeutics

CNS

희귀 유전 중추신경계 질환 (SYNGAP1, Rett
syndrome)

ASO

Antisense Oligonucleotides (ASO)

$60m

$907m

Biogen*

Ionis Pharmaceutical

CNS

척수성 근위축증

ASO

Antisense Oligonucleotides (ASO)

$60m

u/d

MSD

Aligos Therapeutics

Gastroenterology, Metabolic

NASH

ASO

Oligonucleotide

u/d

u/d

Novartis

Alnylam

Gastroenterology

간 질환

siRNA

siRNA-based targeted therapy

u/d

u/d

Pfizer

BioNTech

Infectious Disease

대상포진

mRNA

mRNA-based vaccine

$225m

$200m

BioNTech

Crescendo Biologics

Oncology

종양 및 다양한 질환

mRNA

New precision immunotherapies including mRNA-encoded antibodies

$40m

$750

    Small Molecules

Biohaven

KU Leuven

CNS

신경병성 통증 질환

small molecules

TRPM3 antagonist

u/d

u/d

Cullinan Oncology

Mount Sinai

Oncology

종양

degrader

Small molecule protein degraders targeting HPK1

u/d

u/d

Fusion Pharmaceutical

Pepscan Therapeutics

Oncology

고형암

peptide

Peptide-based radiopharmaceutical (Targeted Alpha Therapies)

u/d

u/d

Amgen

Arrakis Therapeutics

u/d

u/d

degrader

RNA degrader small molecules

$75m

u/d

    Others

Pfizer

Codex DNA

Infectious Disease

다양한 질환

EDS

Enzymatic DNA synthesis (EDS) technology

u/d

u/d

Pfizer

Acuitas Therapeutics

Infectious Disease

다양한 질환

delivery system

LNP delivery system

u/d

u/d

Roche

Freenome

Oncology

종양

diagnostic

Cancer blood testing (liquid biopsy)

$290m

$1b

AstraZeneca

Scorpion Therapeutics

Oncology

종양

u/d

New modality focused on transcription factors to control gene expression and regulate cell processes

$75m

$1.5b